Liraglutide

• Do not use if you:

  • Are allergic to liraglutide or any of the ingredients in the medication.

  • Have a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).

  • Are pregnant, planning to become pregnant, or breastfeeding.

• Consult a doctor before use if you:

  • Have a history of pancreatitis, gallbladder disease, kidney disease, or severe gastrointestinal problems.

  • Are taking other medications to manage blood sugar, such as insulin or sulfonylureas, as using these with liraglutide may increase the risk of hypoglycaemia (low blood sugar).

  • Have diabetic retinopathy or any other significant medical conditions that may require closer monitoring.

• Discontinue use and seek medical attention if:

  • You experience severe and persistent stomach pain, with or without nausea and vomiting (possible signs of pancreatitis).

  • You notice a lump or swelling in your neck, develop hoarseness, or have difficulty swallowing (potential signs of thyroid problems).

  • You develop symptoms of gallbladder disease, such as pain in the upper right abdomen, fever, or jaundice.

Not suitable for use in children: Liraglutide for weight management is not approved for use in children under 18 years of age.

Keep out of reach of children: This is a prescription medication and should only be used by the person for whom it has been prescribed.

• Dosage:

Liraglutide is administered as a once-daily injection, with the starting dose typically at 0.6 mg per day. Your healthcare provider will gradually increase the dose, usually at weekly intervals, until the recommended maintenance dose is reached, depending on your response to treatment.

• Administration:

Inject liraglutide under the skin (subcutaneous injection) in the abdomen, thigh, or upper arm. Rotate injection sites to help prevent irritation. Follow the instructions provided by your healthcare provider for the correct injection technique.

• Take with or without food:

Liraglutide can be injected at any time of day, with or without meals, but it should be taken at approximately the same time each day. Maintaining a healthy diet and regular physical activity will help achieve the best results.

• Do not exceed the prescribed dose:

If you miss a dose, take it as soon as you remember, provided it is within 12 hours of your usual dosing time. If more than 12 hours have passed, skip the missed dose and take your next dose at the usual time. Do not take an extra dose or double the dose to make up for a missed one.

• Store properly:

Store liraglutide in the refrigerator before first use. After first use, the pen can be stored either in the refrigerator or at room temperature for up to 30 days. Do not freeze the medication, and keep the pen cap on to protect it from light.

• Active Ingredient:

Liraglutide (available in various strengths): A glucagon-like peptide-1 (GLP-1) receptor agonist that helps regulate blood sugar, reduce appetite, and support weight loss.

• Inactive Ingredients:

  • Disodium phosphate dihydrate

  • Propylene glycol

  • Phenol

  • Hydrochloric acid and/or sodium hydroxide (for pH adjustment)

  • Water for injections

These ingredients help ensure the stability, sterility, and effective delivery of the active ingredient.

Common Side Effects:

1. Nausea: A common reaction, especially during the first few weeks of treatment or after a dose increase.
2. Diarrhoea or constipation: Digestive upset is frequently reported but often improves as your body adjusts to the medication.
3. Vomiting: Can occur, particularly during the early stages of treatment.

Less Common but Serious Side Effects:

1. Pancreatitis: Symptoms include severe abdominal pain, nausea, and vomiting. Seek immediate medical attention if these occur.
2. Gallbladder problems: Pain in the upper right abdomen, fever, or jaundice may indicate gallstones or other gallbladder conditions.
3. Low blood sugar (hypoglycaemia): More likely if liraglutide is used alongside other diabetes medications such as insulin or sulfonylureas.

Rare Side Effects:

1. Thyroid tumours: Report any neck swelling, difficulty swallowing, or persistent hoarseness to your healthcare provider.
2. Kidney problems: Signs include reduced urine output, swelling in the hands or feet, or dehydration caused by severe vomiting or diarrhoea.
3. Allergic reactions: Rash, itching, swelling of the face, lips, tongue, or throat, or difficulty breathing may indicate a serious allergic reaction and require immediate medical attention.

• How does Liraglutide work?

Liraglutide is a GLP-1 receptor agonist that helps regulate blood sugar by stimulating insulin release when blood sugar levels are high, reducing glucagon production, and slowing stomach emptying. It also helps regulate appetite, making you feel fuller for longer and reducing food intake.

• How does Liraglutide aid in weight loss?

Liraglutide reduces appetite and increases feelings of fullness, helping you eat fewer calories. When used alongside a healthy diet and regular physical activity, it can support significant weight loss.

• How is Liraglutide administered?

Liraglutide is given as a once-daily subcutaneous injection (under the skin). You can inject it into the abdomen, thigh, or upper arm. A healthcare provider will show you how to administer the injection correctly.

• Are there any side effects?

Common side effects include nausea, vomiting, diarrhoea, constipation, and stomach pain. Serious side effects, such as pancreatitis or gallbladder problems, are rare but possible.

• Can Liraglutide be used by individuals without diabetes?

Yes. Depending on the brand and indication, liraglutide is approved for weight management in eligible adults with obesity or those who are overweight with weight-related health conditions, as well as for the treatment of type 2 diabetes. Always consult a healthcare provider to determine whether liraglutide is suitable for you.